Senior Scientist/Associate Director Translational Medicine
(Clinical Biomarker and Diagnostics)

Harpoon Therapeutics (ticker: HARP) is a clinical-stage immunotherapy company developing a novel class of T cell engagers that harness the power of the body’s immune system to treat patients suffering from cancer and other diseases. T cell engagers are engineered proteins that direct a patient’s own T cells to kill target cells that express specific proteins, or antigens, carried by the target cells. Using its proprietary Tri-specific T cell Activating Construct (TriTAC®) platform, Harpoon is developing a pipeline of novel TriTACs initially focused on the treatment of solid tumors and hematologic malignancies. HPN424 targets PSMA and is in a Phase 1/2a trial for metastatic castration-resistant prostate cancer. HPN536 targets mesothelin and is in a Phase 1/2a trial for cancers expressing mesothelin, initially focused on ovarian and pancreatic cancers. HPN217 targets BCMA and is in a Phase 1/2 trial for relapsed, refractory multiple myeloma. HPN328 targets DLL3 and is in a Phase 1/2 trial for cancers expressing DLL3, initially focused on small cell lung cancer and other tumors with high-grade neuroendocrine features. Harpoon is led by an experienced management team. The company emphasizes a collegial, collaborative environment and has a strong record of scientific innovation, pioneering protein engineering, expertise in tumor immunology and pre-clinical and clinical research. For additional information about Harpoon Therapeutics, please visit

We are seeking a highly motivated individual to lead the development, execution, and data analysis of exploratory pharmacodynamic (PD) endpoint and biomarkers as well as companion diagnostic strategies for multiple clinical development programs.

Key Responsibilities

  • Provide scientific leadership in diagnostics development
  • Contribute to the development and execution of clinical Biomarker / companion diagnostics strategies as part of drug development
  • Collaborate with members of Product Development Team (PDT) and outside CROs to drive and implement program-specific diagnostics strategies for clinical development molecules
  • Develop diagnostics related regulatory strategies and participate in interactions with health authorities
  • Represent PDT on diagnostics related activities in decision-making committees such as executive management and board of directors
  • Contribute to scientific presentations and publications targeted to the scientific and biotech community

Skills and Qualifications

  • PhD in a relevant field of biomedical research, e.g., cancer biology, cell biology, molecular biology, pharmacology, or immunology with at least 5 years post-doctoral experience in industry/academic setting (title commensurate with experience)
  • Expertise and hands on experience in cancer drug target discovery, characterization, and validation utilizing various cell-, protein-, and/or transcript-based experimental techniques that may include immunohistochemistry, immunofluorescence microscopy, flow cytometry, in vivo imaging, and/or gene expression profiling
  • Experience in diagnostics development for patient selection, pharmacodynamic marker evaluation, and regulatory knowledge in diagnostics development are major pluses
  • Industry experience in cancer immunotherapy, translational science and biomarker development is preferred
  • Excellent verbal and written communication; strong organizational and interpersonal skills
  • Ability to establish priorities, operate with a sense of urgency in a dynamic, fast-paced, timeline-driven environment