Senior Scientist, Protein Mass Spectrometry

Harpoon Therapeutics is a clinical-stage immuno-oncology company focused on the discovery and development of novel, proprietary bispecific T cell-engaging biologic drug candidates for the treatment of various cancers. Harpoon’s lead candidate, HPN424, is in clinical development for prostate cancer, with a second candidate, HPN536, in clinical testing for mesothelin-overexpressing tumors, such as lung, pancreatic and ovarian cancers. Two additional programs are projected to enter clinical development by the end of 2020. Harpoon is led by an experienced management team and has raised more than $200 million from leading life science investors.

We are seeking a highly motivated individual who can lead efforts to characterize research protein identity, chemical liabilities and stability. As an integral member of the Protein Science group, this individual will partner with the Biology, New Technologies, and Product Development groups to develop our proprietary platforms, select leads and characterize our clinical candidates. The ideal candidate will manage a group with diverse functions, title commensurate with experience.

Key Responsibilities

  • Establish and lead mass spectrometry functions in house and manage CRO analyses as required
  • Develop intact mass methods for diverse research and therapeutic molecules
  • Execute peptide maps to identify PTMs and liabilities of therapeutic molecules and inform engineering, cell line and formulation development
  • Expand methods to quantify biotransformation of therapeutic molecules in complex matrices
  • Manage transfer of product specific stability indicating methods to CROs
  • Maintain records, prepare reports, make presentations to update senior leadership
  • Manage a laboratory-based team

Skills and Qualifications

  • PhD with 2-5 years’ relevant experience, biotechnology industry preferred
  • Extensive training in protein mass spectrometry, biochemistry and biophysics
  • Demonstrated aptitude in native mass spectrometry, peptide mapping, PTM characterization
  • Proficiency in spectrophotometry, electrophoresis, fluorescence, and light scattering characterization of proteins desired
  • Ability to work independently, design, execute, interpret and troubleshoot experiments
  • Excellent verbal and written communication, strong organizational and interpersonal skills
  • Prior direct managerial experience valuable