Senior Scientist, Biophysical Characterization

Harpoon Therapeutics is a clinical-stage immuno-oncology company focused on the discovery and development of novel, proprietary bispecific T cell engaging biologics for the treatment of various cancers. Harpoon’s first product, HPN424, is in clinical development for prostate cancer, and our second product HPN536 is in clinical testing for mesothelin over-expressing tumors, such as lung, pancreatic and ovarian cancers. Harpoon has two additional products in preclinical development and continues to build its pipeline and technology platforms. Harpoon is led by an experienced management team and has raised more than $200 million from leading life science investors. The company emphasizes a collegial, collaborative environment and has a strong record of scientific innovation, pioneering protein engineering, with expertise in tumor immunology and clinical research.

We are seeking a highly motivated individual who can lead efforts to characterize biomolecular interactions and assess research protein quality and stability. As an integral member of the Protein Science group, this individual will partner with the Biology, New Technologies, and Product Development groups to develop our proprietary platforms, select leads and characterize our clinical candidates. The ideal candidate will manage a small group with diverse functions, title commensurate with experience.

Key Responsibilities

  • Design, execute, and evaluate kinetics experiments for quantification of monovalent and bispecific protein:protein interactions
  • Perform routine protein chemistry manipulations to generate and purify research reagents
  • Execute methods to characterize protein quality and stability
  • Develop, validate and transfer product specific methods and reagents
  • Maintain records, prepare reports, make presentations to update senior leadership
  • Manage a laboratory-based team

Skills and Qualifications

  • Extensive training in Biochemistry, Biophysics or related fields
  • PhD with 5-10 years’ relevant experience, biotechnology industry preferred
  • Demonstrated aptitude in biophysical characterization, a deep understanding of binding kinetics, prior experience with Bio-layer interferometry preferred
  • Proficiency in chromatography, spectrophotometry, electrophoresis, fluorescence, and light scattering characterization of proteins essential
  • Ability to work independently, design, execute, interpret and troubleshoot experiments
  • Familiarity with intact protein and peptide mass spectrometry desirable
  • Excellent verbal and written communication, strong organizational and interpersonal skills
  • Prior direct managerial experience valuable