Senior Manager/Associate Director, Project Management

Harpoon Therapeutics is a clinical-stage immunotherapy company located in South San Francisco. Harpoon Therapeutics is a clinical-stage immunotherapy company developing a novel class of T cell engagers that harness the power of the body’s immune system to treat patients suffering from cancer and other diseases. T cell engagers are engineered proteins that direct a patient’s own T cells to kill target cells that express specific proteins, or antigens, carried by the target cells. Using its proprietary Tri-specific T cell Activating Construct (TriTAC®) platform, Harpoon is developing a pipeline of novel TriTACs initially focused on the treatment of solid tumors and hematologic malignancies. HPN217 targets BCMA and is in a Phase 1/2 trial for relapsed, refractory multiple myeloma. HPN328 targets DLL3 and is in a Phase 1/2 trial for small cell lung cancer and other DLL3-associated tumors. HPN536 targets mesothelin and is in a Phase 1/2a trial for cancers expressing mesothelin, initially focused on ovarian and pancreatic cancers. Harpoon has also developed a proprietary ProTriTAC™ platform, which applies a prodrug concept to its TriTAC platform to create a therapeutic T cell engager that remains inactive until it reaches the tumor. The company’s third proprietary technology platform, extended release TriTAC-XR, is designed to mitigate cytokine release syndrome. Harpoon is led by an experienced management team. The company emphasizes a collegial, collaborative environment and has a strong record of scientific innovation, pioneering protein engineering, expertise in tumor immunology and pre-clinical and clinical research. For additional information about Harpoon Therapeutics, please visit


We are seeking a highly motivated individual as Project Manager. This individual will report into the Head of Program Management and play an essential role in supporting the Project Team Leaders (PTL) and project teams perform cross-functional drug development activities of pipeline products at Harpoon. The Senior Manager or Associate Director of Project Management serves as a strategic partner to project team leaders in the execution of the strategic vision of the program. You will drive the development and execution of high quality, integrated cross-functional project plans for one or more products in support of the overall program strategy. In addition, you may be asked to lead and/or participate in special department, cross-functional, or team projects.

Key Responsibilities

  • Identify key deliverables for each function and their inter-dependencies
  • Work with multiple project teams to develop study project plans that delineate team objectives, activities, timelines, and resources required
  • Drive cross functional planning for key drug development stage-gate decision points (e.g., First in Human, End of Phase 2, Filing, and Launch)
  • Implement best practices and ensure cross-functional alignment and accountability
  • Identify project issues or resource gaps and drive resolution
  • Monitor and communicate progress and adherence to timelines
  • Facilitate resource planning, financial and capacity assessments
  • Conduct risk management, contingency and scenario planning using a variety of project management tools
  • Identify and efficiently resolve issues, driving decisions, and tracking action items
  • Develop strong partnerships with external business partners and strategic alliances, where applicable
  • Serve as a single point of contact for cross-functional project team information (content and quality)
  • Communicate cross-functional project information at project team meetings, governance meetings and to other stakeholders, as appropriate

Skills and Qualifications

  • At a minimum, a bachelor's degree in nursing, science or health related field required
  • At least 2 years of oncology experience
  • 6-8 years of project manager experience in drug development, clinical project management experience highly desirable
  • Clinical research knowledge and cross-functional understanding of clinical trial methodology
  • History of motivating others to deliver to important milestones while maintaining a positive, transparent and collaborative team environment
  • Capable creating/updating detailed cross functional project timelines and to guide and align study team members in terms of planning and executing against the timelines
  • Ability to establish priorities, operate with a sense of urgency and collaborate (interpersonal, relationship management) with the project study team, CMC team, other sub teams, as well other cross functional team members
  • Ability to generate high quality meeting minutes and project materials, such as presentations, action trackers, budget and cross functional resource plans in conjunction with the PTL, team members and functional leads
  • Must display strong analytical and highly proactive problem-solving skills
  • Excellent verbal and written communication, strong organizational and interpersonal skills
  • Ability to work both independently and collaboratively with cross-functional teams
  • Ability to work in a dynamic, fast-paced, timeline-based environment

Harpoon anticipates that the annual base salary for this position could range from between $160,000 to $190,000 and will depend, in part, on the successful candidate’s credentials for the role, including education, qualifications, and type as well as length of experience. Any offered salary is also based on internal equity, internal salary ranges, market data, and the position’s wage range. The salary range listed does not include any applicable bonuses or long-term incentives, differential pay or other forms of compensation or benefits. Harpoon is a multistate employer and the salary offered will be market competitive. At Harpoon, it is not typical for an individual to be hired at or near the top of the range for their role and compensation decisions are dependent on the facts and circumstances of each case.