Senior Research Associate, Biology

Harpoon Therapeutics is a clinical-stage immunotherapy company located in South San Francisco. Harpoon Therapeutics is a clinical-stage immunotherapy company developing a novel class of T cell engagers that harness the power of the body’s immune system to treat patients suffering from cancer and other diseases. T cell engagers are engineered proteins that direct a patient’s own T cells to kill target cells that express specific proteins, or antigens, carried by the target cells. Using its proprietary Tri-specific T cell Activating Construct (TriTAC®) platform, Harpoon is developing a pipeline of novel TriTACs initially focused on the treatment of solid tumors and hematologic malignancies. HPN217 targets BCMA and is in a Phase 1/2 trial for relapsed, refractory multiple myeloma. HPN328 targets DLL3 and is in a Phase 1/2 trial for small cell lung cancer and other DLL3-associated tumors. HPN536 targets mesothelin and is in a Phase 1/2a trial for cancers expressing mesothelin, initially focused on ovarian and pancreatic cancers. Harpoon has also developed a proprietary ProTriTAC™ platform, which applies a prodrug concept to its TriTAC platform to create a therapeutic T cell engager that remains inactive until it reaches the tumor. The company’s third proprietary technology platform, extended release TriTAC-XR, is designed to mitigate cytokine release syndrome. Harpoon is led by an experienced management team. The company emphasizes a collegial, collaborative environment and has a strong record of scientific innovation, pioneering protein engineering, expertise in tumor immunology and pre-clinical and clinical research. For additional information about Harpoon Therapeutics, please visit

Position Overview

The Research Biology group at Harpoon Therapeutics seeks a Senior Research Associate to join our team, supporting both preclinical and clinical program progression.  Applicants should be capable of working flexibly and expeditiously in a collaborative, innovative and inspiring environment. The ideal candidate will have opportunities to perform mammalian cell culture, stable cell line generation, luciferase assays, flow cytometry, and bioassay automation.

Key Responsibilities

  • Following SOPs to set up and run bioassays for screening and potency measurements.
  • Testing of samples in support of both preclinical development and clinical programs, assay development and optimization, and collection of data in support of regulatory filings. 
  • Culture of mammalian cell lines (adherent and non-adherent) and primary immune cells
  • Development and optimization of cell-based and biochemical assays
  • Operate a variety of instruments including but not limited to liquid handlers, flow cytometers, and plate readers, etc.
  • Maintain records concerning experimental planning, data, and analysis in an electronic laboratory notebook
  • Presentation and discussion of data generated


  • BS and 3 + or MS 1 + years of relevant biotechnology experience with a degree in Cell Biology, Biochemistry, or a related field is required at a minimum.
  • Strong skills in culturing mammalian cell lines and primary cells
  • Experience with cell based and biochemical assays
  • Flow cytometry or fluorescent microscopy experience
  • Ability to work independently with limited supervision
  • Being capable of planning out a work schedule yet remaining flexible to changing priorities
  • Strong organizational, critical thinking, data analysis, and problem-solving skills
  • Good communication skills, good planning, and an ability to meet deadlines are essential.
  • Ability to maintain detailed experimental documentation
  • Robotics and liquid handling device experience a plus