Scientist, Biology

Harpoon Therapeutics is a clinical-stage immunotherapy company developing a novel class of T cell engagers that harness the power of the body’s immune system to treat patients suffering from cancer and other diseases. T cell engagers are engineered proteins that direct a patient’s own T cells to kill target cells that express specific proteins, or antigens, carried by the target cells. Using its proprietary Tri-specific T cell Activating Construct (TriTAC®) platform, Harpoon is developing a pipeline of novel TriTACs initially focused on the treatment of solid tumors and hematologic malignancies. HPN424 targets PSMA and is in a Phase 1/2a trial for metastatic castration-resistant prostate cancer. HPN536 targets mesothelin and is in a Phase 1/2a trial for cancers expressing mesothelin, initially focused on ovarian and pancreatic cancers. HPN217 targets BCMA and is in a Phase 1/2 trial for relapsed, refractory multiple myeloma. HPN328 targets DLL3 and is in a Phase 1/2 trial for small cell lung cancer and other DLL3-associated tumors. Harpoon has also developed a proprietary ProTriTAC™ platform, which applies a prodrug concept to its TriTAC platform to create a therapeutic T cell engager that remains inactive until it reaches the tumor. For additional information about Harpoon Therapeutics, please visit

The New Technology Group at Harpoon is working to enable the safe targeting of previously intractable therapeutic targets by developing novel conditionally active biologic prodrugs that are preferentially active in tumors or other disease microenvironments. We are currently seeking a highly motivated Scientist to advance therapeutic candidates through preclinical proof-of-concept, propose development strategies, and help establish a pipeline of conditionally active biologic prodrugs.

Key Responsibilities

  • Conceive, design, and perform preclinical proof-of-concept experiments to help build a pipeline of novel protease-activated biologic prodrugs
  • Collaborate with other internal research and development functional groups and mentor Research Associates as necessary
  • Help manage work with external CROs, including bioanalytical assay development as well as nonclinical pharmacology and toxicology studies
  • Prepare and present data at internal and external meetings, keep accurate and update-to-date records, assist with legal (IP) and regulatory (IND) filings

Skills and Qualifications

  • PhD in immunology, biology, biochemical engineering, or a related discipline required, with 1-4 years of postdoctoral or industry experience preferred
  • Proficiency in standard cell biology and biochemistry techniques required with experience in mammalian cell culture, multi-color flow cytometry, cell-based assays, and protein bioanalysis desired
  • Rigorous and meticulous experimentalist with robust data analysis and interpretation skills
  • Demonstrated ability to work independently and as a team on multiple concurrent projects
  • Effective communication and organization skills