Research Associate, Biology

Harpoon Therapeutics is a clinical-stage immunotherapy company developing a novel class of T cell engagers that harness the power of the body’s immune system to treat patients suffering from cancer and other diseases. T cell engagers are engineered proteins that direct a patient’s own T cells to kill target cells that express specific proteins, or antigens, carried by the target cells. Using its proprietary Tri-specific T cell Activating Construct (TriTAC®) platform, Harpoon is developing a pipeline of novel TriTACs initially focused on the treatment of solid tumors and hematologic malignancies. HPN424 targets PSMA and is in a Phase 1/2a trial for metastatic castration-resistant prostate cancer. HPN536 targets mesothelin and is in a Phase 1/2a trial for cancers expressing mesothelin, initially focused on ovarian and pancreatic cancers. HPN217 targets BCMA and is in a Phase 1/2 trial for relapsed, refractory multiple myeloma. HPN328 targets DLL3 and is in a Phase 1/2 trial for small cell lung cancer and other DLL3-associated tumors. Harpoon has also developed a proprietary ProTriTAC™ platform, which applies a prodrug concept to its TriTAC platform to create a therapeutic T cell engager that remains inactive until it reaches the tumor. For additional information about Harpoon Therapeutics, please visit

The Research Biology group at Harpoon Therapeutics seeks a Research Associate to join our team. Responsibilities include testing of samples in support of both preclinical development and clinical programs, assay development and optimization, and collection of data in support of regulatory filings. Applicants should be capable of working flexibly and expeditiously in a collaborative, innovative and inspiring environment. The ideal candidate will have experience with mammalian cell culture, stable cell line generation, luciferase assays, flow cytometry, and bioassay automation. Good communication skills, good planning, and an ability to meet deadlines are essential.

Key Responsibilities:

  • Following SOPs to set up and run bioassays for screening and potency measurements
  • Culture of mammalian cell lines (adherent and non-adherent) and primary immune cells
  • Characterization and optimization of cell-based and biochemical assays
  • Operate a variety of instruments including but not limited to liquid handlers, flow cytometers, and plate readers, etc.
  • Being capable of planning out a work schedule yet remaining flexible to changing priorities
  • Maintenance of records concerning experimental planning, data, and analysis in an electronic laboratory notebook
  • Presentation and discussion of data generated


  • BS or MS in Cell Biology, Biochemistry, or a related field with 1+ years of relevant experience
  • Strong skills in culturing mammalian cell lines and primary cells
  • Experience with cell based and biochemical assays
  • Flow cytometry or fluorescent microscopy experience
  • Ability to work independently with limited supervision
  • Strong organizational, critical thinking, data analysis, and problem-solving skills
  • Ability to maintain detailed experimental documentation
  • Robotics and liquid handling device experience a plus