Clinical Finance Manager

Harpoon Therapeutics (ticker: HARP) is a clinical-stage immunotherapy company developing a novel class of T cell engagers that harness the power of the body’s immune system to treat patients suffering from cancer and other diseases. T cell engagers are engineered proteins that direct a patient’s own T cells to kill target cells that express specific proteins, or antigens, carried by the target cells. Using its proprietary Tri-specific T cell Activating Construct (TriTAC®) platform, Harpoon is developing a pipeline of novel TriTACs initially focused on the treatment of solid tumors and hematologic malignancies. HPN424 targets PSMA and is in a Phase 1/2a trial for metastatic castration-resistant prostate cancer. HPN536 targets mesothelin and is in a Phase 1/2a trial for cancers expressing mesothelin, initially focused on ovarian and pancreatic cancers. HPN217 targets BCMA and is in a Phase 1/2 trial for relapsed, refractory multiple myeloma. HPN328 targets DLL3 and Harpoon plans to initiate a Phase 1/2 trial in the second half of 2020. Harpoon is led by an experienced management team. The company emphasizes a collegial, collaborative environment and has a strong record of scientific innovation, pioneering protein engineering, expertise in tumor immunology and pre-clinical and clinical research. For additional information about Harpoon Therapeutics, please visit

Reporting to the Senior Director, Financial Planning & Analysis, this individual will be a critical liaison between the Finance and Clinical Operations departments. This position has a diverse scope of responsibilities that includes vendor financial management, project tracking, oversight of the procure-to-pay processes and budgeting/forecasting of clinical trials. This position will work closely with the Clinical Operations team to ensure the accurate and timely processing of monthly accruals, invoices, purchase order management, support for budgeting and forecasting information as well as vendor selection, contracting, and change order management.


  • Create and maintain clinical trial budgets working with Clinical Operations and Finance teams
  • Support forecasting clinical trial spend and ad hoc analysis on costs of clinical trials
  • Track overall progress of various projects relative to contracts/budget/purchase order
  • Develop and maintain the clinical trial and other accrual models in MS Excel.
  • Create and monitor Purchase Orders for all Clinical Agreements
  • Review all clinical invoices and track payments against SOW budgets
  • Coordinate with CRO and EDC vendors to review and validate Investigator Site Invoices against CTA budgets and enrollment data
  • Liaise/collaborate with Harpoon Clinical Operations team and vendors to gain an understanding of departmental contracts, SOWs, purchase orders, and various other projects
  • Participate in Project Team Meetings and other Clinical Operations Team meetings as necessary
  • Assist the Clinical Operations team with Change Order analysis and processing
  • Support RFP Quantitative Analysis and Vendor Selection
  • Assist in Vendor Management and Oversight
  • Assist in negotiating the Clinical Trial Agreement (CTA) Budgets with Investigator Sites

Skills and Qualifications

  • Minimum of BS degree in accounting or finance required
  • Minimum 5+ years of experience in Clinical Finance or a similar role in the biotech space
  • Ability to meet deadlines, multi-task, and work under pressure to ensure a timely close without sacrificing quality
  • Strong organization and time management skills
  • Excellent communication skills (written and verbal)
  • Excellent attention to detail
  • Excellent analytical and problem-solving skills
  • Excellent teamwork and collaboration skills with the ability to work independently
  • Have a mindset for continuous improvement and growth in a growing and evolving organization
  • Proficient using Microsoft Office Suite tools, Coupa, NetSuite and Planful/Host Analytics
  • Good business judgment and a strong understanding of clinical trial conduct
  • Clinical Operations background is a plus