Associate Director, Research

Harpoon Therapeutics is a clinical-stage immunotherapy company located in South San Francisco. The company is developing novel biologics that harness the power of the body’s immune system to treat patients suffering from cancer and other diseases. Using its proprietary Tri-specific T cell Activating Construct (TriTAC®) platform, Harpoon is developing a pipeline of novel T cell engagers initially focused on the treatment of solid tumors and hematologic malignancies. HPN424 targets PSMA and is in a Phase 1/2a trial for metastatic castration-resistant prostate cancer. HPN536 targets mesothelin and is in a Phase 1/2a trial for cancers expressing mesothelin, initially focused on ovarian, pancreatic cancers and mesothelioma. HPN217 targets BCMA and is in a Phase 1/2 trial for relapsed, refractory multiple myeloma. HPN328 targets DLL3 and is in a Phase 1/2 trial for small cell lung cancer and other DLL3-expressing tumors. Harpoon has also developed a proprietary ProTriTAC™ platform, which applies a prodrug concept to its TriTAC platform to create a therapeutic T cell engager that remains inactive until it reaches the tumor microenvironment. Harpoon is led by an experienced management team. The company emphasizes a collegial, collaborative environment and has a strong record of scientific innovation, pioneering protein engineering, expertise in tumor immunology and pre-clinical and clinical research. For additional information about Harpoon Therapeutics, please visit 

Job Summary

We are seeking an Associate Director to lead a team of researchers and develop new T cell engager programs from idea to IND candidates. You’ll be a key member of the research group responsible for the next-generation protease-activated T cell engagers that are designed to be activated at the right place and time for improved drug efficacy and tolerability.


  • Direct the research and preclinical development of T cell engager programs from idea to IND candidates
  • Plan and design in vitro and in vivo proof-of-concept experiments (including rodent efficacy and non-human primate tox studies) to advance preclinical pipeline programs
  • Analyze experimental data and communicate research findings to all levels of audience
  • Lead, manage, and mentor a team of scientists and research associates


  • PhD in any biology-related field with 5 + years of industry experience in drug discovery is required
  • Ability to collaborate across teams and disciplines
  • Prior experience managing a research group is preferred, but not required.
  • Prior experience or competency in any of the following areas is preferred, but not required:
    • Experience developing immunology or oncology therapeutic agents
    • Validation of novel oncology targets
    • Development of molecular, biochemical, or cell-based assays
    • Design or implementation of in vivo pharmacology and toxicology experiments
    • Development of bioanalytical assays
    • In-depth knowledge of protease biology
  • Effective communication skills in presenting to internal (scientists, project teams) and external (scientific conferences, publication) audiences