Senior Director, Project Team Leader

Harpoon Therapeutics (ticker: HARP) is a clinical-stage immunotherapy company developing a novel class of T cell engagers that harness the power of the body’s immune system to treat patients suffering from cancer and other diseases. T cell engagers are engineered proteins that direct a patient’s own T cells to kill target cells that express specific proteins, or antigens, carried by the target cells. Using its proprietary Tri-specific T cell Activating Construct (TriTAC®) platform, Harpoon is developing a pipeline of novel TriTACs initially focused on the treatment of solid tumors and hematologic malignancies. HPN424 targets PSMA and is in a Phase 1/2a trial for metastatic castration-resistant prostate cancer. HPN536 targets mesothelin and is in a Phase 1/2a trial for cancers expressing mesothelin, initially focused on ovarian and pancreatic cancers, and mesothelioma. HPN217 targets BCMA and is in a Phase 1/2 trial for relapsed, refractory multiple myeloma. HPN328 targets DLL3 and is in a Phase 1/2 trial for cancers expressing DLL3, initially focused on small cell lung cancer and other tumors with high-grade neuroendocrine features. Harpoon is led by an experienced management team. The company emphasizes a collegial, collaborative environment and has a strong record of scientific innovation, pioneering protein engineering, expertise in tumor immunology and pre-clinical and clinical research. For additional information about Harpoon Therapeutics, please visit

We are seeking a highly motivated Sr. Director, Project Team Lead to drive cross-functional teams to develop a strategy to drive the company’s assets forward.

Key Responsibilities

  • Lead cross-functional Product Development Team(s) to develop, adapt and drive an integrated global product strategy which incorporates short- and long-term cross-functional impacts as well as region and country perspective
  • Works closely to influence, advise and coordinate strategic and operational efforts across all key product development functions, including Development, Regulatory, Safety, CMC, and Clinical Operations, to ensure strategic alignment and seamless execution
  • Generate high quality, focused communication of program needs and recommendations to executive management
  • Drive team objective setting, prioritization and ensure adherence to plan and strategy
  • Drive risk management, issue identification and resolution and contingency planning
  • Leads the project team and reviews development plans for assigned projects and thorough product lifecycle management for assigned projects
  • Contributes to objective setting and appraisal of core team members for program related activities
  • Ensures high performance team effectiveness

Skills and Qualifications

  • Demonstrated experience working on late stage product development, including regulatory filings (BLA/NDA, sBLAs/sNDAs), and product launches/life cycle management is strongly preferred
  • Minimum of 10 years of experience in drug development in pharmaceuticals, biopharmaceuticals, or biotechnology
  • Ph.D., MD or MBA or advanced degree in biomedical sciences or one of the disciplines related to drug development
  • Solid understanding of CMC, pharmacology, toxicology, PK, and clinical requirements to support major regulatory filings – IND, BLA/NDA/MAA
  • Proven ability to lead and influence data-driven strategy planning and implementation
  • A proactive and strategic thinker, with strong decision-making skills
  • Strong leadership and communication skills (including presentation skills) with success in influencing all levels cross-functionally
  • Experience in biologics and oncology is desirable
  • Ability to assimilate data, recognize key variables and analyze complex situations. Make quality judgments
  • Strong organizational and interpersonal skills
  • Ability to work in a dynamic, fast-paced, timeline-based environment