Careers

Scientist/Senior Scientist, Biomarkers, Translational Medicine

Description

Harpoon Therapeutics (ticker: HARP) is a clinical-stage immunotherapy company developing a novel class of T cell engagers that harness the power of the body’s immune system to treat patients suffering from cancer and other diseases. T cell engagers are engineered proteins that direct a patient’s own T cells to kill target cells that express specific proteins, or antigens, carried by the target cells. Using its proprietary Tri-specific T cell Activating Construct (TriTAC®) platform, Harpoon is developing a pipeline of novel TriTACs initially focused on the treatment of solid tumors and hematologic malignancies. HPN424 targets PSMA and is in a Phase 1/2a trial for metastatic castration-resistant prostate cancer. HPN536 targets mesothelin and is in a Phase 1/2a trial for cancers expressing mesothelin, initially focused on ovarian and pancreatic cancers, and mesothelioma. HPN217 targets BCMA and is in a Phase 1/2 trial for relapsed, refractory multiple myeloma. HPN328 targets DLL3 and is in a Phase 1/2 trial for cancers expressing DLL3, initially focused on small cell lung cancer and other tumors with high-grade neuroendocrine features. Harpoon is led by an experienced management team. The company emphasizes a collegial, collaborative environment and has a strong record of scientific innovation, pioneering protein engineering, expertise in tumor immunology and pre-clinical and clinical research. For additional information about Harpoon Therapeutics, please visit www.harpoontx.com

The Biomarker Team is recruiting a motivated scientist to be a part of a highly impactful functional group in Harpoon’s clinical development programs to (i) design and implement biomarker collection and analysis strategy and (ii) to evaluate how patient characteristics and heterogeneity affect their response (clinical benefits and side effects) to Harpoon’s experimental drugs.

RESPONSIBILITIES

  • Lead scientist in biomarker research for one or more clinical programs:
    • Work with clinical operation and sample management, and with CROs to ensure proper collection and testing of samples.
    • Analyze and interpret biomarker data in conjunction with clinical data in collaboration with colleagues in clinical science and statistical programming.
    • Attend cross-functional team meetings, present biomarker findings to key stakeholders (medical director, project team, management), and offer insights that can be translated into actionable plans to advance the program.
    • Communicate findings to the public in scientific meetings and peer-reviewed journals.
    • Author documents for regulatory submissions, clinical study protocols and reports.
    • Review and modify biomarker assays as needed periodically.
  • Draw on experience and knowledge of the field, participate in the design of pharmacodynamic (PD) biomarker assays such as serum cytokine profiling and peripheral blood T cell phenotyping. 
  • Conduct pilot experiments in the laboratory to support assay development.  
  • Be a team player by assisting colleagues within and outside of the department.

Skills and QUALIFICATIONS

  • A PhD in immunology or a relevant field of study in biology is required, preferably with 1-4 years of postdoctoral or industry experience.
  • Proficiency in standard cell biology techniques such as mammalian cell culture, cell-based assays using cell lines and human peripheral blood cells is required.
  • Proficiency in multi-color (4+) flow cytometry assay design, sample preparation, data acquisition and analysis is required.
  • Hands-on experience in immunohistochemistry, immunofluorescent microscopy, qPCR, high-throughput sequencing, or mouse models of human cancers are highly desirable.
  • Basic knowledge or proficiency in data management software for storage, organization and analysis of complex datasets is a major plus.
  • Effective communication skills in presenting to internal (scientists, project teams) and external (scientific conferences, publications) audiences.