Research Associate/Sr. Research Associate, Protein Science

Harpoon Therapeutics is a clinical-stage immuno-oncology company focused on the discovery and development of novel T cell engaging biologics for the treatment of various cancers based on proprietary technology platforms. Harpoon’s first product, HPN424, is in clinical development for prostate cancer. Our second product HPN536 is in clinical testing for mesothelin over-expressing tumors, such as lung, pancreatic and ovarian cancers, while our third product HPN217 is in clinical testing for multiple myeloma. Harpoon has additional product candidates in preclinical development and continues to build its pipeline and technology platforms. Harpoon is led by an experienced management team and has raised more than $200 million from leading life science investors. The company emphasizes a collegial, collaborative environment and has a strong record of scientific innovation, pioneering protein engineering, with expertise in tumor immunology and clinical research. We are seeking a highly motivated individual who enjoys detail-oriented technical work, can manage diverse responsibilities in the lab, and thrives in a fast-paced work environment. As an integral member of our functional group, this individual will work closely with other team members within Protein Science and partner with other functional areas including Biology, New Technologies, and Translational Medicine. The ideal candidate will have 1-5 years of experience in the purification of difficult proteins, operation and troubleshooting of AKTA Pure/AVANT, and performing standard lab biochemical techniques to validate the quality of purified proteins.


  • Execution of multi-step protein purification schemes using AKTA Unicorn-based methods
  • Chromatography sample preparation and protein formulation
  • SDS-PAGE, Spectrophotometry, Analytical SEC, and Western blot analysis of purified proteins
  • Protein chemistry, conjugation, and validation of reagent molecules for assays
  • Purification process development for Harpoon clinical candidates and transfer to CMC
  • Materials management and freezer inventory database maintenance
  • Maintain electronic lab notebook and databases, prepare reports, and make regular presentations to summarize results and update management


  • Training in Biochemistry, Biotechnology, Molecular Biology, or related fields
  • Bachelors + 1-5 years or Masters + 1-3 years of relevant experience in industry or academic lab
  • Experience in protein chemistry e.g. chromatography, labeling and conjugation, or analytics
  • AKTA Pure or Avant and/or Agilent HPLC experience a requirement
  • Experience in Downstream Process Development desirable
  • Demonstrated aptitude for detail-oriented work and following precise SOPs
  • Demonstrated aptitude for learning new techniques and handling diverse tasks concurrently
  • Ability to work independently on a project or with limited direct supervision
  • Fast learner with creative problem-solving ability