Research Associate/Sr. Research Assoc., Translational Medicine (In Vivo Pharmacology)

Harpoon Therapeutics is a clinical-stage immuno-oncology company focused on the discovery and development of novel T cell engaging biologics for the treatment of various cancers based on proprietary technology platforms. Harpoon’s first product, HPN424, is in clinical development for prostate cancer. Our second product HPN536 is in clinical testing for mesothelin over-expressing tumors, such as lung, pancreatic and ovarian cancers, while our third product HPN217 is in clinical testing for multiple myeloma. Harpoon has additional product candidates in preclinical development and continues to build its pipeline and technology platforms. Harpoon is led by an experienced management team and has raised more than $200 million from leading life science investors. The company emphasizes a collegial, collaborative environment and has a strong record of scientific innovation, pioneering protein engineering, with expertise in tumor immunology and clinical research.

We are looking for a highly motivated Research Associate/Sr. Research Associate to join our Translational Medicine group to execute preclinical studies and provide in vivo proof-of-biology data on Harpoon’s drug candidates. This position is laboratory based with the successful candidate collaborating across groups to plan, execute and analyze in vivo studies.


  • Independently design, execute and analyze in vitro, ex vivo, and in vivo tumor model experiments
  • Tumor implantation which includes tissue culture of normal lymphocytes and tumor cell lines, enumeration of cell density and making serial dilutions
  • Treatment of mice with experimental drugs via multiple routes of administration, tumor growth and health monitoring
  • Analyze the outcome of pharmacokinetic, pharmacodynamic and efficacy studies including statistical analyses
  • Perform relevant in vitro experiments to support the advancement of candidates to in vivo studies
  • Maintain records, prepare reports, and make regular presentations to summarize results
  • Adapt to and perform new responsibilities depending on the evolving needs of Harpoon Therapeutics


  • BA/BS or MS with 5+ years’ laboratory experience in cancer biology, biochemistry, immunology or related fields
  • Direct hands on experience with in vivo  studies conducted in mice, including mouse handling, tumor and immune cell implantation, performing routine injections (sc, ip, iv), preparing test compounds, blood and tissue collection is required
  • Proficient in maintaining cell lines in tissue culture
  • Experience in flow cytometry is a major plus
  • Demonstrated ability to work independently with limited supervision
  • Maintain electronic laboratory notebook with high attention to detail
  • Ability to accommodate a flexible schedule which include occasional weekend responsibilities
  • Motivated, flexible, highly productive individual with strong desire to learn new techniques and to understand the scientific rationale for experimental procedures
  • Team player with excellent oral and written communication skills