Research Associate, Protein Purification


Harpoon Therapeutics is a clinical-stage immuno-oncology company focused on the discovery and development of novel T cell engaging biologics for the treatment of various cancers based on proprietary technology platforms. Harpoon’s first product, HPN424, is in clinical development for prostate cancer. Our second product HPN536 is in clinical testing for mesothelin over-expressing tumors, such as lung, pancreatic and ovarian cancers, while our third product HPN217 is in clinical testing for multiple myeloma. Harpoon has additional product candidates in preclinical development and continues to build its pipeline and technology platforms. Harpoon is led by an experienced management team and has raised more than $200 million from leading life science investors. The company emphasizes a collegial, collaborative environment and has a strong record of scientific innovation, pioneering protein engineering, with expertise in tumor immunology and clinical research.

We are seeking a highly motivated individual who enjoys detail-oriented technical work, manage diverse responsibilities in the lab, and thrives in a fast-paced work environment. As an integral member of our functional group, this individual will work closely with other team members within Protein Science and partner with other functional areas in the organization including Biology and Translational medicine. The ideal candidate will have strong technical aptitude for lab and instrument work, and a problem-solving mindset that is diligent and flexible. Our company is 5 years old and our Reseach group is comprised of a small but diverse group of staff members with a wide range of scientific experience and backgrounds.


  • Execution of multi-step protein purification by diverse chromatography using AKTA Unicorn-based methods
  • Chromatography sample preparation and protein formulation
  • SDS-PAGE, Spectrometry, HPLC Analytical SEC, and Western blot analysis of purified proteins
  • Protein chemistry, conjugation, and validation of reagent molecules for assays
  • Materials management and inventory database maintenance
  • Maintain electronic lab notebook entries, update databases in the cloud, prepare reports, and make regular presentations to summarize results and update management


  • Training in Molecular Biology, Biochemistry, Cell Biology, or related fields
  • Bachelors + 1-5 years / Masters + 1-3 years of relevant experience in industry or academic lab
  • Experience in protein chemistry e.g. chromatography, labeling and conjugation, or analytics
  • Experience in aseptic cell culture techniques
  • Demonstrated aptitude for detail-oriented work and following precise SOPs
  • Demonstrated aptitude for learning new techniques and handling diverse tasks concurrently
  • Demonstrated ability to accommodate and communicate well with colleagues
  • Ability to work independently or with limited direct supervision