Research Associate, Protein Purification


Harpoon Therapeutics is a clinical-stage immunotherapy company located in South San Francisco. Harpoon Therapeutics is a clinical-stage immunotherapy company developing a novel class of T cell engagers that harness the power of the body’s immune system to treat patients suffering from cancer and other diseases. T cell engagers are engineered proteins that direct a patient’s own T cells to kill target cells that express specific proteins, or antigens, carried by the target cells. Using its proprietary Tri-specific T cell Activating Construct (TriTAC®) platform, Harpoon is developing a pipeline of novel TriTACs initially focused on the treatment of solid tumors and hematologic malignancies. HPN217 targets BCMA and is in a Phase 1/2 trial for relapsed, refractory multiple myeloma. HPN328 targets DLL3 and is in a Phase 1/2 trial for small cell lung cancer and other DLL3-associated tumors. HPN536 targets mesothelin and is in a Phase 1/2a trial for cancers expressing mesothelin, initially focused on ovarian and pancreatic cancers. Harpoon has also developed a proprietary ProTriTAC™ platform, which applies a prodrug concept to its TriTAC platform to create a therapeutic T cell engager that remains inactive until it reaches the tumor. The company’s third proprietary technology platform, extended release TriTAC-XR, is designed to mitigate cytokine release syndrome. Harpoon is led by an experienced management team. The company emphasizes a collegial, collaborative environment and has a strong record of scientific innovation, pioneering protein engineering, expertise in tumor immunology and pre-clinical and clinical research. For additional information about Harpoon Therapeutics, please visit

We are seeking a highly motivated individual who enjoys detail-oriented technical work, can manage diverse responsibilities in the lab, and thrives in a fast-paced work environment. As an integral member of the Protein Science group, this individual will work closely with other team members within Protein Science and partner with other functional areas in the organization. The ideal candidate will have strong technical aptitude for lab and instrumentation work, and a flexible problem-solving mindset


  • Execution of multi-step protein purification by diverse chromatography using AKTA Unicorn-based methods
  • Chromatography sample preparation and protein formulation
  • SDS-PAGE, Spectrometry, HPLC, and Western blot analysis of purified proteins
  • Protein chemistry, conjugation, and validation of reagent molecules for assays
  • Materials management and inventory database maintenance
  • Maintain electronic lab notebook entries, prepare reports, and make regular presentations to summarize results


  • Training in Molecular Biology, Biochemistry, Cell Biology, or related fields
  • Bachelors + 1-5 years / Masters + 1-2 years of relevant experience in industry or academic lab
  • Protein chemistry experience including e.g., chromatography, conjugation, or analytics
  • Aseptic technique or cell culture experience
  • Demonstrated aptitude for detail-oriented work and following precise protocols
  • Demonstrated aptitude for learning new techniques and handling diverse tasks concurrently
  • Ability to work independently or with limited direct supervision
  • Ability to work and communicate well with other team members