Research Associate, Protein Expression


Harpoon Therapeutics is a clinical-stage immuno-oncology company focused on the discovery and development of novel T cell engaging biologics for the treatment of various cancers based on proprietary technology platforms. Harpoon’s first product, HPN424, is in clinical development for prostate cancer. Our second product HPN536 is in clinical testing for mesothelin over-expressing tumors, such as lung, pancreatic and ovarian cancers, while our third product HPN217 is in clinical testing for multiple myeloma. Harpoon has additional product candidates in preclinical development and continues to build its pipeline and technology platforms. Harpoon is led by an experienced management team and has raised more than $200 million from leading life science investors. The company emphasizes a collegial, collaborative environment and has a strong record of scientific innovation, pioneering protein engineering, with expertise in tumor immunology and clinical research.

We are seeking a highly motivated individual who enjoys detail-oriented technical work, can manage diverse responsibilities in the lab, and thrives in a fast-paced work environment. As an integral member of our functional group, this individual will work closely with other team members within Protein Science and partner with other functional areas in the organization including Biology and Translational Medicine. The ideal candidate will have strong technical aptitude for lab and instrument work, and a problem-solving mindset that is diligent and flexible. Our Research Organization is comprised of a diverse group of scientists with a wide range of experience and backgrounds.


  • Stable and transient transfections of mammalian cell lines
  • Cryopreservation of cell lines and clarification of conditioned medium
  • SDS-PAGE, Octet BLI, and Western blot analysis of purified proteins
  • Materials management and inventory database maintenance
  • Maintenance of electronic lab notebook and databases, preparation of reports, and regular presentations to summarize results and update management


  • Training in Cell Biology, Biochemistry, Molecular Biology, or related fields
  • Bachelors + 1-5 years / Masters + 1-3 years of relevant experience in industry or academic lab
  • Experience in aseptic technique, cell line maintenance, and host cell transfection
  • Experience with single use bioreactors is a plus
  • Experience with biophysical analysis is a plus
  • Demonstrated aptitude for detail-oriented work and following precise SOPs
  • Demonstrated aptitude for learning new techniques and handling diverse tasks concurrently
  • Demonstrated ability to accommodate and communicate well with colleagues
  • Ability to work independently or with limited direct supervision