In Vivo Research Associate, New Technologies (Immuno-oncology)


Harpoon Therapeutics is a clinical-stage immuno-oncology company focused on the discovery and development of novel, proprietary bispecific T cell-engaging biologic drug candidates for the treatment of various cancers. Harpoon’s lead candidate, HPN424, is in clinical development for prostate cancer, with a second candidate, HPN536, in clinical testing for mesothelin overexpressing tumors, such as lung, pancreatic and ovarian cancers. Two additional programs are projected to enter clinical development by the end of 2020. Harpoon is led by an experienced management team and has raised more than $200 million from leading life science investors.


We are currently seeking a Research Associate to join the New Technologies group at Harpoon. Our growing team is focused on the development of novel, conditionally active biologic prodrugs, including our protease-activated T cell engager platform (ProTriTAC). These prodrugs are designed to be preferentially active in the tumor, and thus enable the safe targeting of previously intractable therapeutic targets. The successful candidate will be expected to generate in vivo proof-of-concept data for Harpoon’s ProTriTAC drug candidates, work collaboratively in a team-oriented environment, and have a strong desire to learn new techniques and the underlying scientific rationale.


  • Design and execute in vivo proof-of-concept experiment using mouse tumor models and PK studies
  • Perform mouse tumor models from start to finish: expansion of tumor cell lines and immune cells in vitro, enumeration of cell density, implantation of tumor and immune cells in vivo, measurement of clinical endpoints, and analysis of data
  • Maintain cultures of tumor cell lines and immune cells
  • Prepare test articles with appropriate serial dilutions
  • Dose mice via multiple routes of administration
  • Perform blood collection, tissue extraction, and tissue processing
  • Perform in vitro biochemical and cell-based assays to support in vivo data findings
  • Collect, analyze, and present experimental data regularly at team meetings
  • Maintain clear and complete experimental records with an electronic lab notebook
  • Support project needs as they arise


  • BS or MS in biology or a related discipline with 2+ years of laboratory experience
  • Proficiency with mouse in vivo handling skills, including administration of test articles by sc, ip and iv injections, implantation of tumor and/or immune cells, and collection of blood and tissues
  • Meticulous experimentalist with strong attention to detail
  • Effective verbal and written communication
  • Ability to work independently with limited supervision
  • Ability to accommodate a flexible schedule, which may include occasional weekend responsibilities


  • Direct hands-on experience and working knowledge of in vivo mouse tumor models, including xenograft and/or syngeneic tumor models, and mouse PK studies
  • Ability to design and execute multi-color flow cytometry experiments and analyze data with FlowJo, FACSDiva, or similar analysis programs